Which chronic disease affects the skin and internal organs, producing taut and firm tissue?

Scleroderma is the correct choice as it is a chronic autoimmune disease characterized by the hardening and tightening of the skin and connective tissues, often leading to taut and firm tissue. This condition can indeed affect both the skin and various internal organs, including the heart, lungs, and digestive tract. The word "sclero" refers to hardness in Greek, which aptly describes the primary symptom of this disease—hardened skin and tissue caused by excess collagen production. This process can disrupt normal organ function due to the stiffening of tissues.

The other choices do not relate to the characteristics or impacts of scleroderma. Semenology is not a recognized chronic disease and does not pertain to skin or internal organ issues. Schizophrenia, a mental health disorder, does not involve the physical manifestations described in the question. Sinistraural refers to something on the left side, typically related to anatomy or hearing, and does not pertain to chronic diseases affecting tissue. Therefore, scleroderma stands out as the only condition fitting the specific description in the question.